29,30,38,46,65,66, Overall, 24% of fractures required revision surgery in patients who had received bisphosphonates for less than five years and 20.3% required revision surgery in those who had received bisphosphonates from more than five 81 and the other needed exchange nailing for a nonunion in which secondary fracture displacement occurred after a fall 13 months after prophylactic nailing. 29,30,38,46,50,51,59, 61,65,76 Moreover, taking into account the relationship between the duration and type of bisphosphonates therapy and the incidence of revision surgery, the mean duration of bisphosphonates therapy for an atypical fracture which healed without revision surgery was seven years (1 to 13), while that for an atypical fracture which required revision surgery was seven years, (1 to 20).
38 There was no significant difference in the time to healing between patients who had been treated with bisphosphonates for less than five years and those who had been treated with bisphosphonates for more than five years (p > 0.05), in patients whose individual time to healing and duration of bisphosphonate treatment were both recorded.
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